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==Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain==
==Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain==
<StructureSection load='4ms7' size='340' side='right' caption='[[4ms7]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='4ms7' size='340' side='right'caption='[[4ms7]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ms7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MS7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ms7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MS7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.673&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rzu|3rzu]], [[4jxe|4jxe]], [[4msd|4msd]], [[4msj|4msj]], [[4msm|4msm]], [[4msq|4msq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ms7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms7 OCA], [http://pdbe.org/4ms7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ms7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ms7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ms7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms7 OCA], [https://pdbe.org/4ms7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ms7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ms7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SST2_SCHPO SST2_SCHPO]] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.<ref>PMID:17660439</ref>
[https://www.uniprot.org/uniprot/SST2_SCHPO SST2_SCHPO] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.<ref>PMID:17660439</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Das, C]]
[[Category: Large Structures]]
[[Category: Ronau, J A]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Shrestha, R K]]
[[Category: Das C]]
[[Category: Cytosol]]
[[Category: Ronau JA]]
[[Category: Dequbiquitination]]
[[Category: Shrestha RK]]
[[Category: Helix-beta-helix sandwich]]
[[Category: Hydrolase]]
[[Category: Ubiquitin]]
[[Category: Zinc metalloprotease]]
Retrieved from "https://proteopedia.org/4ms7"