1m24: Difference between revisions

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[[Image:1m24.jpg|left|200px]]


{{Structure
==Trichotoxin_A50E, An Ion Channel-Forming Polypeptide==
|PDB= 1m24 |SIZE=350|CAPTION= <scene name='initialview01'>1m24</scene>, resolution 0.90&Aring;
<StructureSection load='1m24' size='340' side='right'caption='[[1m24]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=VOL:L-VALINOL'>VOL</scene>
<table><tr><td colspan='2'>[[1m24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M24 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=PRD_000160:TRICHOTOXIN+A50E'>PRD_000160</scene>, <scene name='pdbligand=VOL:L-VALINOL'>VOL</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m24 OCA], [https://pdbe.org/1m24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m24 RCSB], [https://www.ebi.ac.uk/pdbsum/1m24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m24 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m24 OCA], [http://www.ebi.ac.uk/pdbsum/1m24 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m24 RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide'''
 
 
==Overview==
Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
 
==About this Structure==
1M24 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA].
 
==Reference==
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12390019 12390019]
[[Category: Protein complex]]
[[Category: Trichoderma viride]]
[[Category: Trichoderma viride]]
[[Category: Brueckner, H.]]
[[Category: Brueckner H]]
[[Category: Chugh, J K.]]
[[Category: Chugh JK]]
[[Category: Wallace, B A.]]
[[Category: Wallace BA]]
[[Category: antibiotic]]
[[Category: helical bundle]]
[[Category: ion channel]]
[[Category: peptaibol]]
 
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Retrieved from "https://proteopedia.org/1m24"