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==Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP==
==Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP==
<StructureSection load='4isw' size='340' side='right' caption='[[4isw]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
<StructureSection load='4isw' size='340' side='right'caption='[[4isw]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4isw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ISW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4isw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ihi|3ihi]], [[4iqq|4iqq]], [[4irr|4irr]], [[4g9u|4g9u]], [[4iqb|4iqb]], [[4e5o|4e5o]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isw OCA], [https://pdbe.org/4isw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isw RCSB], [https://www.ebi.ac.uk/pdbsum/4isw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isw ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isw OCA], [http://pdbe.org/4isw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4isw RCSB], [http://www.ebi.ac.uk/pdbsum/4isw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4isw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9Y052_CAEEL Q9Y052_CAEEL]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caenorhabditis elegans]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Banaszak, K]]
[[Category: Banaszak K]]
[[Category: Dowiercial, A]]
[[Category: Dowiercial A]]
[[Category: Jarmula, A]]
[[Category: Jarmula A]]
[[Category: Rode, W]]
[[Category: Rode W]]
[[Category: Rypniewski, W]]
[[Category: Rypniewski W]]
[[Category: Wilk, P]]
[[Category: Wilk P]]
[[Category: Deoxynucleotide biosynthesis]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Protein homodimer]]
[[Category: Transferase]]

Latest revision as of 10:59, 6 November 2024

Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP

4isw, resolution 3.14Å

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