4br1: Difference between revisions
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==Protease-induced heterodimer of human triosephosphate isomerase.== | ==Protease-induced heterodimer of human triosephosphate isomerase.== | ||
<StructureSection load='4br1' size='340' side='right' caption='[[4br1]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4br1' size='340' side='right'caption='[[4br1]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4br1]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4br1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BR1 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4br1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4br1 OCA], [https://pdbe.org/4br1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4br1 RCSB], [https://www.ebi.ac.uk/pdbsum/4br1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4br1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | |||
==See Also== | ==See Also== | ||
*[[Triose | *[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Castillo-Villanueva | [[Category: Castillo-Villanueva A]] | ||
[[Category: DeLaMora-DeLaMora | [[Category: DeLaMora-DeLaMora I]] | ||
[[Category: Enriquez-Flores | [[Category: Enriquez-Flores S]] | ||
[[Category: Garcia-Torres | [[Category: Garcia-Torres I]] | ||
[[Category: Gomez-Manzo | [[Category: Gomez-Manzo S]] | ||
[[Category: Hernandez-Alcantara | [[Category: Hernandez-Alcantara G]] | ||
[[Category: Lopez-Velazquez | [[Category: Lopez-Velazquez G]] | ||
[[Category: Marcial-Quino | [[Category: Marcial-Quino J]] | ||
[[Category: Mendez | [[Category: Mendez ST]] | ||
[[Category: Mendoza-Hernandez | [[Category: Mendoza-Hernandez G]] | ||
[[Category: Oria-Hernandez | [[Category: Oria-Hernandez J]] | ||
[[Category: Reyes-Vivas | [[Category: Reyes-Vivas H]] | ||
[[Category: Torres-Arroyo | [[Category: Torres-Arroyo A]] | ||
[[Category: Torres-Larios | [[Category: Torres-Larios A]] | ||
Latest revision as of 11:56, 20 December 2023
Protease-induced heterodimer of human triosephosphate isomerase.
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