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==Crystal structure of diaminopimelate epimerase Mycobacterium tuberculosis DapF==
==Crystal structure of diaminopimelate epimerase Mycobacterium tuberculosis DapF==
<StructureSection load='3fve' size='340' side='right' caption='[[3fve]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3fve' size='340' side='right'caption='[[3fve]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVE FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapF, MT2798, MTCY154.06c, Rv2726c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fve OCA], [https://pdbe.org/3fve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fve RCSB], [https://www.ebi.ac.uk/pdbsum/3fve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fve ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fve OCA], [http://pdbe.org/3fve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fve RCSB], [http://www.ebi.ac.uk/pdbsum/3fve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fve ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DAPF_MYCTU DAPF_MYCTU]] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.<ref>PMID:16907737</ref> <ref>PMID:18269631</ref>
[https://www.uniprot.org/uniprot/DAPF_MYCTU DAPF_MYCTU] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.<ref>PMID:16907737</ref> <ref>PMID:18269631</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fve_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fve_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Diaminopimelate epimerase]]
[[Category: Large Structures]]
[[Category: Besra, G S]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Dover, L G]]
[[Category: Besra GS]]
[[Category: Futterer, K]]
[[Category: Dover LG]]
[[Category: Roper, D I]]
[[Category: Futterer K]]
[[Category: Usha, V]]
[[Category: Roper DI]]
[[Category: Alpha/beta]]
[[Category: Usha V]]
[[Category: Amino-acid biosynthesis]]
[[Category: Isomerase]]
[[Category: Lysine biosynthesis]]
Retrieved from "https://proteopedia.org/3fve"