2ykd: Difference between revisions

==Structure of the matrix protein from human respiratory syncytial virus==

<StructureSection load='2ykd' size='340' side='right'caption='[[2ykd]], [[Resolution|resolution]] 1.86&Aring;' scene=''>

<table><tr><td colspan='2'>[[2ykd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKD FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykd OCA], [https://pdbe.org/2ykd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykd RCSB], [https://www.ebi.ac.uk/pdbsum/2ykd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykd ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref>  

[[Category: Human orthopneumovirus]]

[[Category: Large Structures]]

[[Category: Beeby A]]

[[Category: Carlisle JL]]

[[Category: McPhee HK]]

[[Category: Money VA]]

[[Category: Sanderson JM]]

[[Category: Watson SMD]]

[[Category: Yeo RP]]