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==Crystal Structure of Choline Oxidase in Complex with the Reaction Product Glycine Betaine==
==Crystal Structure of Choline Oxidase in Complex with the Reaction Product Glycine Betaine==
<StructureSection load='4mjw' size='340' side='right' caption='[[4mjw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4mjw' size='340' side='right'caption='[[4mjw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mjw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_globiformis"_(conn_1928)_bergey_et_al._1930 "achromobacter globiformis" (conn 1928) bergey et al. 1930]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MJW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mjw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MJW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jbv|2jbv]], [[3nne|3nne]], [[3ljp|3ljp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">codA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1665 "Achromobacter globiformis" (Conn 1928) Bergey et al. 1930])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mjw OCA], [https://pdbe.org/4mjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mjw RCSB], [https://www.ebi.ac.uk/pdbsum/4mjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mjw ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_oxidase Choline oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.17 1.1.3.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mjw OCA], [http://pdbe.org/4mjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mjw RCSB], [http://www.ebi.ac.uk/pdbsum/4mjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mjw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CHOX_ARTGO CHOX_ARTGO]] Catalyzes the two-step oxidative conversion of choline to glycine-betaine with betaine aldehyde as an intermediate. Glycine-betaine accumulates to high levels in the cytoplasm of cells to prevent dehydration and plasmolysis in adverse hyperosmotic environments. Accepts either choline or the reaction intermediate betaine-aldehyde as substrate.<ref>PMID:12795615</ref>
[https://www.uniprot.org/uniprot/CHOX_ARTGO CHOX_ARTGO] Catalyzes the two-step oxidative conversion of choline to glycine-betaine with betaine aldehyde as an intermediate. Glycine-betaine accumulates to high levels in the cytoplasm of cells to prevent dehydration and plasmolysis in adverse hyperosmotic environments. Accepts either choline or the reaction intermediate betaine-aldehyde as substrate.<ref>PMID:12795615</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Choline oxidase]]
[[Category: Arthrobacter globiformis]]
[[Category: Gadda, G]]
[[Category: Large Structures]]
[[Category: Salvi, F]]
[[Category: Gadda G]]
[[Category: Wang, Y F]]
[[Category: Salvi F]]
[[Category: Weber, I T]]
[[Category: Wang Y-F]]
[[Category: Choline]]
[[Category: Weber IT]]
[[Category: Fad binding]]
[[Category: Glucose-methanol-choline]]
[[Category: Glycine betaine]]
[[Category: Oxidase]]
[[Category: Oxidoreductase]]
[[Category: Reaction product]]
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