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==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408==
==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408==
<StructureSection load='4h2m' size='340' side='right' caption='[[4h2m]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='4h2m' size='340' side='right'caption='[[4h2m]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h2m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H2M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h2m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0YV:2,2-{BENZENE-1,3-DIYLBIS[ETHYNE-2,1-DIYL(5-BROMOBENZENE-3,1-DIYL)]}DIETHANAMINE'>0YV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h2j|4h2j]], [[4h2o|4h2o]], [[4h38|4h38]], [[4h3a|4h3a]], [[4h3c|4h3c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0YV:2,2-{BENZENE-1,3-DIYLBIS[ETHYNE-2,1-DIYL(5-BROMOBENZENE-3,1-DIYL)]}DIETHANAMINE'>0YV</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uppS, ispU, rth, yaeS, b0174, JW0169 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2m OCA], [https://pdbe.org/4h2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2m RCSB], [https://www.ebi.ac.uk/pdbsum/4h2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2m ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ditrans,polycis-undecaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-_diphosphate_specific) Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2m OCA], [http://pdbe.org/4h2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h2m RCSB], [http://www.ebi.ac.uk/pdbsum/4h2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Oldfield, E]]
[[Category: Large Structures]]
[[Category: Zhu, W]]
[[Category: Oldfield E]]
[[Category: Alpha-helix]]
[[Category: Zhu W]]
[[Category: Cell wall biosynthesis]]
[[Category: Farnesyl diphosphate binding]]
[[Category: Isopentenyl diphosphate binding]]
[[Category: Prenyl transferase]]
[[Category: Prenyl transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4h2m"