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==Crystal structure of mouse Glutaminase C, BPTES-bound form==
==Crystal structure of mouse Glutaminase C, BPTES-bound form==
<StructureSection load='4jkt' size='340' side='right' caption='[[4jkt]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
<StructureSection load='4jkt' size='340' side='right'caption='[[4jkt]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jkt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JKT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jkt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=04A:N,N-[SULFANEDIYLBIS(ETHANE-2,1-DIYL-1,3,4-THIADIAZOLE-5,2-DIYL)]BIS(2-PHENYLACETAMIDE)'>04A</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ss3|3ss3]], [[3ss4|3ss4]], [[3ss5|3ss5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04A:N,N-[SULFANEDIYLBIS(ETHANE-2,1-DIYL-1,3,4-THIADIAZOLE-5,2-DIYL)]BIS(2-PHENYLACETAMIDE)'>04A</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gls, Gls1, Kiaa0838 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkt OCA], [https://pdbe.org/4jkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jkt RCSB], [https://www.ebi.ac.uk/pdbsum/4jkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkt ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkt OCA], [http://pdbe.org/4jkt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jkt RCSB], [http://www.ebi.ac.uk/pdbsum/4jkt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLSK_MOUSE GLSK_MOUSE]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.<ref>PMID:16641247</ref> <ref>PMID:22373647</ref> <ref>PMID:22228304</ref>
[https://www.uniprot.org/uniprot/GLSK_MOUSE GLSK_MOUSE] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.<ref>PMID:16641247</ref> <ref>PMID:22373647</ref> <ref>PMID:22228304</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Glutaminase|Glutaminase]]
*[[Glutaminase 3D structures|Glutaminase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutaminase]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Ambrosio, A L.B]]
[[Category: Ambrosio ALB]]
[[Category: Dias, S M.G]]
[[Category: Dias SMG]]
[[Category: Ferreira, A P.S]]
[[Category: Ferreira APS]]
[[Category: Fornezari, C]]
[[Category: Fornezari C]]
[[Category: Hydrolase]]
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