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[[Image:1mh2.jpg|left|200px]]


{{Structure
==Crystal Structure of a Zinc Containing Dimer of Phospholipase A2 from the Venom of Indian Cobra (Naja Naja Sagittifera)==
|PDB= 1mh2 |SIZE=350|CAPTION= <scene name='initialview01'>1mh2</scene>, resolution 2.70&Aring;
<StructureSection load='1mh2' size='340' side='right'caption='[[1mh2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[1mh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MH2 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mh2 OCA], [https://pdbe.org/1mh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1mh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mh2 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1lfj|1LFJ]], [[1lff|1LFF]], [[1ln8|1LN8]], [[1mf4|1MF4]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mh2 OCA], [http://www.ebi.ac.uk/pdbsum/1mh2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mh2 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PA2B1_NAJSG PA2B1_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mh2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mh2 ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of a Zinc Containing Dimer of Phospholipase A2 from the Venom of Indian Cobra (Naja Naja Sagittifera)'''
==See Also==
 
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1MH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MH2 OCA].
[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
[[Category: Phospholipase A(2)]]
[[Category: Jabeen T]]
[[Category: Protein complex]]
[[Category: Paramasivam M]]
[[Category: Jabeen, T.]]
[[Category: Sharma S]]
[[Category: Paramasivam, M.]]
[[Category: Singh N]]
[[Category: Sharma, S.]]
[[Category: Singh RK]]
[[Category: Singh, N.]]
[[Category: Singh TP]]
[[Category: Singh, R K.]]
[[Category: Srinivasan A]]
[[Category: Singh, T P.]]
[[Category: Varma AK]]
[[Category: Srinivasan, A.]]
[[Category: Varma, A K.]]
[[Category: complex]]
[[Category: enzyme]]
[[Category: phospholipase a2]]
[[Category: phospholipid]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:01 2008''

Latest revision as of 07:01, 30 October 2024

Crystal Structure of a Zinc Containing Dimer of Phospholipase A2 from the Venom of Indian Cobra (Naja Naja Sagittifera)

1mh2, resolution 2.70Å

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