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[[Image:1mhk.gif|left|200px]]


{{Structure
==Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn==
|PDB= 1mhk |SIZE=350|CAPTION= <scene name='initialview01'>1mhk</scene>, resolution 2.50&Aring;
<StructureSection load='1mhk' size='340' side='right'caption='[[1mhk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
<table><tr><td colspan='2'>[[1mhk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHK FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhk OCA], [https://pdbe.org/1mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhk RCSB], [https://www.ebi.ac.uk/pdbsum/1mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhk ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhk OCA], [http://www.ebi.ac.uk/pdbsum/1mhk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mhk RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn'''
[[Category: Moore PB]]
 
[[Category: Szep S]]
 
[[Category: Wang J]]
==Overview==
A crystal structure has been obtained for a 26-nucleotide RNA that contains the loop E sequence from Chromatium minutissimum. Rather than having a loop E-like conformation, it consists of an A-form helix that splits into two separate strands following a sheared A-G base pair. The backbone of the strand containing the G of the A-G pair makes a turn of almost 180 degrees in the space of two nucleotides, and then interacts with the minor groove of the helix from which it originates. Similar structures, which we call hook-turns, occur in 16S and 23S rRNAs. They are found at places where the two strands of a helix separate at an A/G juxtaposition to interact with other sequences.
 
==About this Structure==
1MHK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHK OCA].
 
==Reference==
The crystal structure of a 26-nucleotide RNA containing a hook-turn., Szep S, Wang J, Moore PB, RNA. 2003 Jan;9(1):44-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12554875 12554875]
[[Category: Protein complex]]
[[Category: Moore, P B.]]
[[Category: Szep, S.]]
[[Category: Wang, J.]]
[[Category: 180 degree turn]]
[[Category: helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:08 2008''

Latest revision as of 07:43, 14 February 2024

Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn

1mhk, resolution 2.50Å

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