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==Schizosaccharomyces pombe DJ-1 T114V mutant==
==Schizosaccharomyces pombe DJ-1 T114V mutant==
<StructureSection load='4ge3' size='340' side='right' caption='[[4ge3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4ge3' size='340' side='right'caption='[[4ge3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ge3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ge3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GE3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gdn|4gdn]], [[4ge0|4ge0]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ge3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge3 OCA], [https://pdbe.org/4ge3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ge3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ge3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPAC22E12.03c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ge3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge3 OCA], [http://pdbe.org/4ge3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ge3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ge3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DJ1_SCHPO DJ1_SCHPO] Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (PubMed:24758716). May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity).[UniProtKB:Q04432]<ref>PMID:24758716</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cbs 356]]
[[Category: Large Structures]]
[[Category: Labunska, T]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Madzelan, P]]
[[Category: Labunska T]]
[[Category: Wilson, M A]]
[[Category: Madzelan P]]
[[Category: Dj-1/pfpi family]]
[[Category: Wilson MA]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/4ge3"