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==Structure of a mutant P44S of Foot-and-mouth disease Virus RNA-dependent RNA polymerase==
==Structure of a mutant P44S of Foot-and-mouth disease Virus RNA-dependent RNA polymerase==
<StructureSection load='3nky' size='340' side='right' caption='[[3nky]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='3nky' size='340' side='right'caption='[[3nky]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphthovirus_c Aphthovirus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NKY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus_C Foot and mouth disease virus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NKY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wne|1wne]], [[1u09|1u09]], [[2e9r|2e9r]], [[2e9t|2e9t]], [[2e9z|2e9z]], [[2ec0|2ec0]], [[3nl0|3nl0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12116 Aphthovirus C])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nky OCA], [https://pdbe.org/3nky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nky RCSB], [https://www.ebi.ac.uk/pdbsum/3nky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nky ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nky OCA], [http://pdbe.org/3nky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nky RCSB], [http://www.ebi.ac.uk/pdbsum/3nky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nky ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO]] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]  
[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aphthovirus c]]
[[Category: Foot and mouth disease virus C]]
[[Category: Agudo, R]]
[[Category: Large Structures]]
[[Category: Arias, A]]
[[Category: Agudo R]]
[[Category: Domingo, E]]
[[Category: Arias A]]
[[Category: Ferrer-Orta, C]]
[[Category: Domingo E]]
[[Category: Perez-Luque, R]]
[[Category: Ferrer-Orta C]]
[[Category: Verdaguer, N]]
[[Category: Perez-Luque R]]
[[Category: 3d polymerase picornavirus]]
[[Category: Verdaguer N]]
[[Category: Foot-and-mouth disease virus rna dependent rna polymerase]]
[[Category: Ribavirin]]
[[Category: Transferase]]
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