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==Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA in complex with an inhibitor.==
==Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA in complex with an inhibitor.==
<StructureSection load='2ya2' size='340' side='right' caption='[[2ya2]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
<StructureSection load='2ya2' size='340' side='right'caption='[[2ya2]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ya2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YA2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ya2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YA2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NOJ:1-DEOXYNOJIRIMYCIN'>NOJ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ya0|2ya0]], [[2j44|2j44]], [[2ya1|2ya1]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ya2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ya2 OCA], [https://pdbe.org/2ya2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ya2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ya2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ya2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ya2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ya2 OCA], [http://pdbe.org/2ya2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ya2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ya2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ya2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PULA_STRPN PULA_STRPN] Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells (PubMed:21565699). Hydrolyzes the alpha-1,6-branchpoints of glycogen (PubMed:20497336, PubMed:21565699). Hydrolyzes pullulan. Does not hydrolyze dextran (PubMed:20497336). Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific carbohydrate-binding protein, which binds to amylose (pure alpha-(1,4)-linked glucose), amylopectin (alpha-(1,4)-linked glucose with alpha-(1,6) branch points), pullulan (linear polymer of mixed alpha-(1,4)- and alpha-(1,6)-linked glucose) and glycogen (similar to amylopectin with more frequent alpha-(1,6) branch points) in vitro. Does not bind to dextran (a linear polymer of alpha-(1,6)-linked glucose) (PubMed:17187076).[UniProtKB:A0A0H2ZL64]<ref>PMID:17187076</ref> <ref>PMID:20497336</ref> <ref>PMID:21565699</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strpn]]
[[Category: Large Structures]]
[[Category: Boraston, A B]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Bueren, A Lammerts van]]
[[Category: Boraston AB]]
[[Category: Burke, R D]]
[[Category: Burke RD]]
[[Category: Czjzek, M]]
[[Category: Czjzek M]]
[[Category: Deng, L]]
[[Category: Deng L]]
[[Category: Ficko-Blean, E]]
[[Category: Ficko-Blean E]]
[[Category: Hehemann, J H]]
[[Category: Hehemann JH]]
[[Category: Higgins, M A]]
[[Category: Higgins MA]]
[[Category: Ogunniyi, A D]]
[[Category: Lammerts van Bueren A]]
[[Category: Paton, J C]]
[[Category: Ogunniyi AD]]
[[Category: Pluvinage, B]]
[[Category: Paton JC]]
[[Category: Stroeher, U H]]
[[Category: Pluvinage B]]
[[Category: Vocadlo, D J]]
[[Category: Stroeher UH]]
[[Category: Warry, N E]]
[[Category: Vocadlo DJ]]
[[Category: Glycoside hydrolase]]
[[Category: Warry NE]]
[[Category: Hydrolase]]
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