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==Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH==
==Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH==
<StructureSection load='4l4v' size='340' side='right' caption='[[4l4v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4l4v' size='340' side='right'caption='[[4l4v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l4v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L4V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l4v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VY:1-DEOXY-1-(7-HYDROXY-6-METHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>1VY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gup|4gup]], [[4l4t|4l4t]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VY:1-DEOXY-1-(7-HYDROXY-6-METHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>1VY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TCR alpha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TCR beta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4v OCA], [https://pdbe.org/4l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4v RCSB], [https://www.ebi.ac.uk/pdbsum/4l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4v OCA], [http://pdbe.org/4l4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l4v RCSB], [http://www.ebi.ac.uk/pdbsum/4l4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4v ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[T-cell receptor|T-cell receptor]]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Beddoe, T]]
[[Category: Large Structures]]
[[Category: Birkinshaw, R W]]
[[Category: Beddoe T]]
[[Category: Brooks, A G]]
[[Category: Birkinshaw RW]]
[[Category: Chen, Z]]
[[Category: Brooks AG]]
[[Category: Corbett, A J]]
[[Category: Chen Z]]
[[Category: Eckle, S B.G]]
[[Category: Corbett AJ]]
[[Category: Fairlie, D P]]
[[Category: Eckle SBG]]
[[Category: Kjer-Nielsen, L]]
[[Category: Fairlie DP]]
[[Category: Liu, L]]
[[Category: Kjer-Nielsen L]]
[[Category: McCluskey, J]]
[[Category: Le Nours J]]
[[Category: Meehan, B]]
[[Category: Liu L]]
[[Category: Miles, J J]]
[[Category: McCluskey J]]
[[Category: Nours, J Le]]
[[Category: Meehan B]]
[[Category: Patel, O]]
[[Category: Miles JJ]]
[[Category: Reantragoon, R]]
[[Category: Patel O]]
[[Category: Rossjohn, J]]
[[Category: Reantragoon R]]
[[Category: Sandoval-Romero, M L]]
[[Category: Rossjohn J]]
[[Category: Sullivan, L C]]
[[Category: Sandoval-Romero ML]]
[[Category: Immune system]]
[[Category: Sullivan LC]]
[[Category: Mait tcr]]
[[Category: Membrane protein-immune system complex]]
[[Category: Mhc class i-related protein]]
[[Category: Vitamin b metabolite]]
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