3ba1: Difference between revisions

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==Structure of hydroxyphenylpyruvate reductase from coleus blumei==
==Structure of hydroxyphenylpyruvate reductase from coleus blumei==
<StructureSection load='3ba1' size='340' side='right' caption='[[3ba1]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
<StructureSection load='3ba1' size='340' side='right'caption='[[3ba1]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ba1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coleus Coleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BA1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ba1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plectranthus_scutellarioides Plectranthus scutellarioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BA1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hppr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4142 Coleus])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxyphenylpyruvate_reductase Hydroxyphenylpyruvate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.237 1.1.1.237] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ba1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba1 OCA], [https://pdbe.org/3ba1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ba1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ba1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ba1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba1 OCA], [http://pdbe.org/3ba1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ba1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ba1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HPPR_PLESU HPPR_PLESU]] Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate.<ref>PMID:15284489</ref>
[https://www.uniprot.org/uniprot/HPPR_PLESU HPPR_PLESU] Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate.<ref>PMID:15284489</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3ba1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3ba1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Coleus]]
[[Category: Large Structures]]
[[Category: Hydroxyphenylpyruvate reductase]]
[[Category: Plectranthus scutellarioides]]
[[Category: Heine, A]]
[[Category: Heine A]]
[[Category: Janiak, V]]
[[Category: Janiak V]]
[[Category: Klebe, G]]
[[Category: Klebe G]]
[[Category: Petersen, M]]
[[Category: Petersen M]]
[[Category: Cofactor binding domain]]
[[Category: Oxidoreductase]]
[[Category: Pyruvate]]
[[Category: Substrate binding domain]]
[[Category: Two domain protein]]

Latest revision as of 14:03, 13 March 2024

Structure of hydroxyphenylpyruvate reductase from coleus blumei

3ba1, resolution 1.47Å

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