2ylf: Difference between revisions
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==Crystal structure of the human Spir-1 KIND domain== | ==Crystal structure of the human Spir-1 KIND domain== | ||
<StructureSection load='2ylf' size='340' side='right' caption='[[2ylf]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='2ylf' size='340' side='right'caption='[[2ylf]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ylf]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ylf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ylf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ylf OCA], [https://pdbe.org/2ylf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ylf RCSB], [https://www.ebi.ac.uk/pdbsum/2ylf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ylf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SPIR1_HUMAN SPIR1_HUMAN] Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.<ref>PMID:11747823</ref> <ref>PMID:21620703</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Kerkhoff | [[Category: Large Structures]] | ||
[[Category: Pechlivanis | [[Category: Kerkhoff E]] | ||
[[Category: Vonrhein | [[Category: Pechlivanis M]] | ||
[[Category: Zeth | [[Category: Vonrhein C]] | ||
[[Category: Zeth K]] | |||