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==Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound==
==Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound==
<StructureSection load='4j14' size='340' side='right' caption='[[4j14]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4j14' size='340' side='right'caption='[[4j14]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J14 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J14 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=X2N:POSACONAZOLE'>X2N</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4enh|4enh]], [[4fia|4fia]], [[3mdm|3mdm]], [[3mdr|3mdr]], [[3mdt|3mdt]], [[3mdv|3mdv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=X2N:POSACONAZOLE'>X2N</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CP46A_HUMAN, CYP46, CYP46A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j14 OCA], [https://pdbe.org/4j14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j14 RCSB], [https://www.ebi.ac.uk/pdbsum/4j14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j14 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholesterol_24-hydroxylase Cholesterol 24-hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.98 1.14.13.98] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j14 OCA], [http://pdbe.org/4j14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j14 RCSB], [http://www.ebi.ac.uk/pdbsum/4j14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j14 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.  
[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Mast, N]]
[[Category: Mast N]]
[[Category: Pikuleva, I A]]
[[Category: Pikuleva IA]]
[[Category: Stout, C D]]
[[Category: Stout CD]]
[[Category: Endoplasmic reticulum]]
[[Category: Enzyme]]
[[Category: Oxidoreductase]]
[[Category: P450]]
[[Category: Posaconazole]]
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