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==Crystal structure of Ag85C co-crystallized with p-chloromercuribenzoic acid==
==Crystal structure of Ag85C co-crystallized with p-chloromercuribenzoic acid==
<StructureSection load='4qdo' size='340' side='right' caption='[[4qdo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4qdo' size='340' side='right'caption='[[4qdo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qdo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QDO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qdo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QDO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.899&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=31Q:(4-CARBOXYPHENYL)(L-CYSTEINATO-KAPPAS~3~)MERCURY'>31Q</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31Q:(4-CARBOXYPHENYL)(L-CYSTEINATO-KAPPAS~3~)MERCURY'>31Q</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qdt|4qdt]], [[4qdu|4qdu]], [[4qdx|4qdx]], [[4qdz|4qdz]], [[4qe3|4qe3]], [[4qek|4qek]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdo OCA], [https://pdbe.org/4qdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qdo RCSB], [https://www.ebi.ac.uk/pdbsum/4qdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qdo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdo OCA], [http://pdbe.org/4qdo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qdo RCSB], [http://www.ebi.ac.uk/pdbsum/4qdo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qdo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A85C_MYCTU A85C_MYCTU]] The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.<ref>PMID:1830294</ref> <ref>PMID:9162010</ref>
[https://www.uniprot.org/uniprot/A85C_MYCTU A85C_MYCTU] The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.<ref>PMID:1830294</ref> <ref>PMID:9162010</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Antigen 85|Antigen 85]]
*[[Antigen 85 3D structures|Antigen 85 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Favrot, L]]
[[Category: Large Structures]]
[[Category: Lajiness, D H]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ronning, D R]]
[[Category: Favrot L]]
[[Category: Diacylglycerol acyltransferase]]
[[Category: Lajiness DH]]
[[Category: Mycolyltransferase]]
[[Category: Ronning DR]]
[[Category: Transferase]]
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