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==Ligand-free structure of CYP142 from Mycobacterium smegmatis==
==Ligand-free structure of CYP142 from Mycobacterium smegmatis==
<StructureSection load='3zby' size='340' side='right' caption='[[3zby]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='3zby' size='340' side='right'caption='[[3zby]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zby]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZBY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zby]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZBY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zby OCA], [http://pdbe.org/3zby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zby RCSB], [http://www.ebi.ac.uk/pdbsum/3zby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zby ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zby OCA], [https://pdbe.org/3zby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zby RCSB], [https://www.ebi.ac.uk/pdbsum/3zby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP142_MYCS2 CP142_MYCS2] Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.<ref>PMID:23489718</ref> <ref>PMID:25210044</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus smegmatis trevisan 1889]]
[[Category: Large Structures]]
[[Category: Frank, D J]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
[[Category: Galan, B]]
[[Category: Frank DJ]]
[[Category: Garcia, J L]]
[[Category: Galan B]]
[[Category: Garcia-Fernandez, E]]
[[Category: Garcia JL]]
[[Category: Kells, P M]]
[[Category: Garcia-Fernandez E]]
[[Category: Montellano, P R.Ortiz de]]
[[Category: Kells PM]]
[[Category: Podust, L M]]
[[Category: Ortiz de Montellano PR]]
[[Category: Cholesterol metabolism]]
[[Category: Podust LM]]
[[Category: Cyp142]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/3zby"