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==Crystal structure of calcium-bound alpha-1 giardin==
==Crystal structure of calcium-bound alpha-1 giardin==
<StructureSection load='4evh' size='340' side='right' caption='[[4evh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4evh' size='340' side='right'caption='[[4evh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4evh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giain Giain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EVH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4evh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4evf|4evf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4evh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evh OCA], [http://pdbe.org/4evh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4evh RCSB], [http://www.ebi.ac.uk/pdbsum/4evh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4evh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4evh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evh OCA], [https://pdbe.org/4evh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4evh RCSB], [https://www.ebi.ac.uk/pdbsum/4evh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4evh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GIA1_GIAIN GIA1_GIAIN]] Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.  
[https://www.uniprot.org/uniprot/GIA1_GIAIN GIA1_GIAIN] Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Giain]]
[[Category: Giardia intestinalis]]
[[Category: Hofmann, A]]
[[Category: Large Structures]]
[[Category: Weeratunga, S]]
[[Category: Hofmann A]]
[[Category: Annexin]]
[[Category: Weeratunga S]]
[[Category: Calcium-binding protein]]
[[Category: Membrane-binding protein]]
[[Category: Metal binding protein]]
Retrieved from "https://proteopedia.org/4evh"