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| ==Crystal Structure Analysis of TT1977== | | ==Crystal Structure Analysis of TT1977== |
| <StructureSection load='2dst' size='340' side='right' caption='[[2dst]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='2dst' size='340' side='right'caption='[[2dst]], [[Resolution|resolution]] 2.00Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[2dst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DST FirstGlance]. <br> | | <table><tr><td colspan='2'>[[2dst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DST FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cyd|2cyd]]</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dst OCA], [http://pdbe.org/2dst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dst RCSB], [http://www.ebi.ac.uk/pdbsum/2dst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dst ProSAT], [http://www.topsan.org/Proteins/RSGI/2dst TOPSAN]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dst OCA], [https://pdbe.org/2dst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dst RCSB], [https://www.ebi.ac.uk/pdbsum/2dst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dst ProSAT], [https://www.topsan.org/Proteins/RSGI/2dst TOPSAN]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/Q5SI36_THET8 Q5SI36_THET8] |
| The gene encoding TTHA1544 is a singleton found in the Thermus thermophilus HB8 genome and encodes a 131-amino-acid protein. The crystal structure of TTHA1544 has been determined at 2.0 A resolution by the single-wavelength anomalous dispersion method in order to elucidate its function. There are two molecules in the asymmetric unit. Each molecule consists of four alpha-helices and six beta-strands, with the beta-strands composing a central beta-sheet. A structural homology search revealed that the overall structure of TTHA1544 resembles the alpha/beta-hydrolase fold, although TTHA1544 lacks the catalytic residues of a hydrolase. These results suggest that TTHA1544 represents the minimized alpha/beta-hydrolase fold and that an additional component would be required for its activity.
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| Structure of the minimized alpha/beta-hydrolase fold protein from Thermus thermophilus HB8.,Xie Y, Takemoto C, Kishishita S, Uchikubo-Kamo T, Murayama K, Chen L, Liu ZJ, Wang BC, Manzoku M, Ebihara A, Kuramitsu S, Shirouzu M, Yokoyama S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt, 12):993-7. Epub 2007 Nov 30. PMID:18084077<ref>PMID:18084077</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2dst" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Flavobacterium thermophilum yoshida and oshima 1971]] | | [[Category: Large Structures]] |
| [[Category: Chen, L]] | | [[Category: Thermus thermophilus]] |
| [[Category: Kishishita, S]] | | [[Category: Chen L]] |
| [[Category: Liu, Z J]] | | [[Category: Kishishita S]] |
| [[Category: Murayama, K]] | | [[Category: Liu ZJ]] |
| [[Category: Structural genomic]]
| | [[Category: Murayama K]] |
| [[Category: Shirouzu, M]] | | [[Category: Shirouzu M]] |
| [[Category: Wang, B C]] | | [[Category: Wang BC]] |
| [[Category: Xie, Y]] | | [[Category: Xie Y]] |
| [[Category: Conserved hypothetical protein]]
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| [[Category: National project on protein structural and functional analyse]]
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| [[Category: Nppsfa]]
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| [[Category: Rsgi]]
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| [[Category: Unknown function]]
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