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==THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C==
==THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C==
<StructureSection load='2vrd' size='340' side='right' caption='[[2vrd]], [[NMR_Ensembles_of_Models | 47 NMR models]]' scene=''>
<StructureSection load='2vrd' size='340' side='right'caption='[[2vrd]], [[NMR_Ensembles_of_Models | 47 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vrd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uw2 1uw2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vrd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uw2 1uw2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrd OCA], [http://pdbe.org/2vrd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vrd RCSB], [http://www.ebi.ac.uk/pdbsum/2vrd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrd ProSAT], [http://www.topsan.org/Proteins/RSGI/2vrd TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrd OCA], [https://pdbe.org/2vrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrd RCSB], [https://www.ebi.ac.uk/pdbsum/2vrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrd ProSAT], [https://www.topsan.org/Proteins/RSGI/2vrd TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RU1C_HUMAN RU1C_HUMAN]] Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.<ref>PMID:2136774</ref> <ref>PMID:1826349</ref> <ref>PMID:8798632</ref>   
[[https://www.uniprot.org/uniprot/RU1C_HUMAN RU1C_HUMAN]] Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.<ref>PMID:2136774</ref> <ref>PMID:1826349</ref> <ref>PMID:8798632</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Hernandez, H]]
[[Category: Hernandez, H]]
[[Category: Muto, Y]]
[[Category: Muto, Y]]
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[[Category: Spliceosomal protein]]
[[Category: Spliceosomal protein]]
[[Category: U1 snrnp]]
[[Category: U1 snrnp]]
[[Category: Zinc]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/2vrd"