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==Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone==
==Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone==
<StructureSection load='3rx2' size='340' side='right' caption='[[3rx2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3rx2' size='340' side='right'caption='[[3rx2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RX2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SLO:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFONYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SLO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rx3|3rx3]], [[3rx4|3rx4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SLO:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFONYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SLO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx2 OCA], [https://pdbe.org/3rx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3rx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx2 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx2 OCA], [http://pdbe.org/3rx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.  
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Chen, J]]
[[Category: Chen J]]
[[Category: Hu, X]]
[[Category: Hu X]]
[[Category: Luo, H]]
[[Category: Luo H]]
[[Category: Zheng, X]]
[[Category: Zheng X]]
[[Category: Aldose reductase]]
[[Category: Oxidoreductase]]

Latest revision as of 17:20, 1 November 2023

Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone

3rx2, resolution 1.90Å

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