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==Crystal structure of S147Q of Rv2613c from Mycobacterium tuberculosis==
==Crystal structure of S147Q of Rv2613c from Mycobacterium tuberculosis==
<StructureSection load='3wo5' size='340' side='right' caption='[[3wo5]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='3wo5' size='340' side='right'caption='[[3wo5]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WO5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ano|3ano]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_adenylyltransferase ATP adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.53 2.7.7.53] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo5 OCA], [https://pdbe.org/3wo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo5 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo5 OCA], [http://pdbe.org/3wo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wo5 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU]] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: ATP adenylyltransferase]]
[[Category: Large Structures]]
[[Category: Arakawa, Y]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mori, S]]
[[Category: Arakawa Y]]
[[Category: Shibayama, K]]
[[Category: Mori S]]
[[Category: Wachino, J]]
[[Category: Shibayama K]]
[[Category: Diadenosine polyphosphate]]
[[Category: Wachino J]]
[[Category: Hit motif]]
[[Category: Mycobacterium]]
[[Category: Phosphorylase]]
[[Category: Transferase]]

Latest revision as of 13:18, 8 November 2023

Crystal structure of S147Q of Rv2613c from Mycobacterium tuberculosis

3wo5, resolution 2.79Å

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