2ww4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==a triclinic crystal form of E. coli 4-diphosphocytidyl-2C-methyl-D- erythritol kinase==
==a triclinic crystal form of E. coli 4-diphosphocytidyl-2C-methyl-D- erythritol kinase==
<StructureSection load='2ww4' size='340' side='right' caption='[[2ww4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2ww4' size='340' side='right'caption='[[2ww4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ww4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WW4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ww4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WW4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-(cytidine_5'-diphospho)-2-C-methyl-D-erythritol_kinase 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.148 2.7.1.148] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ww4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww4 OCA], [http://pdbe.org/2ww4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ww4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ww4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ww4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ww4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww4 OCA], [https://pdbe.org/2ww4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ww4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ww4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ww4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISPE_ECO8A ISPE_ECO8A]] Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity).  
[https://www.uniprot.org/uniprot/ISPE_ECOLI ISPE_ECOLI] Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (PubMed:10570138, PubMed:10655484, Ref.6). Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate (PubMed:10570138).<ref>PMID:10570138</ref> <ref>PMID:10655484</ref> [REFERENCE:6]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2ww4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2ww4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 33: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Gabrielsen, M]]
[[Category: Large Structures]]
[[Category: Hunter, W N]]
[[Category: Gabrielsen M]]
[[Category: Kalinowska-Tluscik, J]]
[[Category: Hunter WN]]
[[Category: Leonard, G A]]
[[Category: Kalinowska-Tluscik J]]
[[Category: Mcsweeney, S M]]
[[Category: Leonard GA]]
[[Category: Miallau, L]]
[[Category: McSweeney SM]]
[[Category: Isoprenoid biosynthesis]]
[[Category: Miallau L]]
[[Category: Kinase]]
[[Category: Non-mevalonate pathway]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2ww4"