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==Crystal structure of human coxsackievirus A16 uncoating intermediate (space group P4232)==
==Crystal structure of human coxsackievirus A16 uncoating intermediate (space group P4232)==
<StructureSection load='4jgy' size='340' side='right' caption='[[4jgy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4jgy' size='340' side='right'caption='[[4jgy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jgy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cv-a16 Cv-a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jgy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGY FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgy OCA], [http://pdbe.org/4jgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jgy RCSB], [http://www.ebi.ac.uk/pdbsum/4jgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgy ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgy OCA], [https://pdbe.org/4jgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgy RCSB], [https://www.ebi.ac.uk/pdbsum/4jgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611]  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]  
[https://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611]  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jgy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jgy" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cv-a16]]
[[Category: Coxsackievirus A16]]
[[Category: Axford, D]]
[[Category: Large Structures]]
[[Category: Fry, E E]]
[[Category: Axford D]]
[[Category: Gao, Q]]
[[Category: Fry EE]]
[[Category: Gilbert, R J]]
[[Category: Gao Q]]
[[Category: Hu, Z]]
[[Category: Gilbert RJ]]
[[Category: Li, X]]
[[Category: Hu Z]]
[[Category: Mcauley, K]]
[[Category: Li X]]
[[Category: Porta, C]]
[[Category: Mcauley K]]
[[Category: Rao, Z]]
[[Category: Porta C]]
[[Category: Ren, J]]
[[Category: Rao Z]]
[[Category: Rowlands, D J]]
[[Category: Ren J]]
[[Category: Stuart, D I]]
[[Category: Rowlands DJ]]
[[Category: Sun, Y]]
[[Category: Stuart DI]]
[[Category: Walter, T S]]
[[Category: Sun Y]]
[[Category: Wang, J]]
[[Category: Walter TS]]
[[Category: Wang, X]]
[[Category: Wang J]]
[[Category: Williams, M]]
[[Category: Wang X]]
[[Category: Yin, W]]
[[Category: Williams M]]
[[Category: Zhao, Y]]
[[Category: Yin W]]
[[Category: Hand-foot-and-mouth disease]]
[[Category: Zhao Y]]
[[Category: Icosahedral virus]]
[[Category: Picornavirus uncoating]]
[[Category: Pocket factor]]
[[Category: Virus]]
Retrieved from "https://proteopedia.org/4jgy"