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==Thymidine phosphorylase from E.coli with 3'-azido-2'-fluoro-dideoxyuridine==
==Thymidine phosphorylase from E.coli with 3'-azido-2'-fluoro-dideoxyuridine==
<StructureSection load='4ead' size='340' side='right' caption='[[4ead]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4ead' size='340' side='right'caption='[[4ead]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ead]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EAD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ead]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EAD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0NP:2,3-DIDEOXY-2-FLUORO-3-TRIAZA-1,2-DIEN-2-IUM-1-YLURIDINE'>0NP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eaf|4eaf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NP:2,3-DIDEOXY-2-FLUORO-3-TRIAZA-1,2-DIEN-2-IUM-1-YLURIDINE'>0NP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b4382, deoA, JW4345, tpp, ttg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ead FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ead OCA], [https://pdbe.org/4ead PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ead RCSB], [https://www.ebi.ac.uk/pdbsum/4ead PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ead ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ead FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ead OCA], [http://pdbe.org/4ead PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ead RCSB], [http://www.ebi.ac.uk/pdbsum/4ead PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ead ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYPH_ECOLI TYPH_ECOLI]] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.  
[https://www.uniprot.org/uniprot/TYPH_ECOLI TYPH_ECOLI] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Thymidine phosphorylase]]
[[Category: Large Structures]]
[[Category: Abramchik, Y A]]
[[Category: Abramchik YA]]
[[Category: Esipov, R S]]
[[Category: Esipov RS]]
[[Category: Kuranova, I P]]
[[Category: Kuranova IP]]
[[Category: Timofeev, V I]]
[[Category: Timofeev VI]]
[[Category: Transferase-transferase inhibitor complex]]