3hz5: Difference between revisions

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==Crystal structure of Hsp90 with fragment Z064==
==Crystal structure of Hsp90 with fragment Z064==
<StructureSection load='3hz5' size='340' side='right' caption='[[3hz5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3hz5' size='340' side='right'caption='[[3hz5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HZ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HZ5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Z64:N-[4-(5-FURAN-2-YL-3-METHYL-1H-PYRAZOL-4-YL)BUTYL]-N-METHYL-7H-PURIN-6-AMINE'>Z64</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hyy|3hyy]], [[3hyz|3hyz]], [[3hz1|3hz1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z64:N-[4-(5-FURAN-2-YL-3-METHYL-1H-PYRAZOL-4-YL)BUTYL]-N-METHYL-7H-PURIN-6-AMINE'>Z64</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hz5 OCA], [http://pdbe.org/3hz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hz5 RCSB], [http://www.ebi.ac.uk/pdbsum/3hz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hz5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hz5 OCA], [https://pdbe.org/3hz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hz5 RCSB], [https://www.ebi.ac.uk/pdbsum/3hz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hz5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/3hz5_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/3hz5_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Barker, J]]
[[Category: Large Structures]]
[[Category: Cheng, R K.Y]]
[[Category: Barker J]]
[[Category: Felicetti, B]]
[[Category: Cheng RKY]]
[[Category: Mather, O]]
[[Category: Felicetti B]]
[[Category: Palan, S]]
[[Category: Mather O]]
[[Category: Whittaker, M]]
[[Category: Palan S]]
[[Category: Atp-binding]]
[[Category: Whittaker M]]
[[Category: Chaperone]]
[[Category: Nucleotide binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
Retrieved from "https://proteopedia.org/3hz5"