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==Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and INH)==
==Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and INH)==
<StructureSection load='3oig' size='340' side='right' caption='[[3oig]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='3oig' size='340' side='right'caption='[[3oig]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3oig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OIG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3oig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OIG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMJ:(2E)-N-[(1,2-DIMETHYL-1H-INDOL-3-YL)METHYL]-N-METHYL-3-(7-OXO-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-3-YL)PROP-2-ENAMIDE'>IMJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oic|3oic]], [[3oid|3oid]], [[3oif|3oif]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMJ:(2E)-N-[(1,2-DIMETHYL-1H-INDOL-3-YL)METHYL]-N-METHYL-3-(7-OXO-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-3-YL)PROP-2-ENAMIDE'>IMJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oig OCA], [https://pdbe.org/3oig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oig RCSB], [https://www.ebi.ac.uk/pdbsum/3oig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oig ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oig OCA], [http://pdbe.org/3oig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oig RCSB], [http://www.ebi.ac.uk/pdbsum/3oig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oig ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FABI_BACSU FABI_BACSU]] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism.<ref>PMID:11007778</ref>
[https://www.uniprot.org/uniprot/FABI_BACSU FABI_BACSU] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism.<ref>PMID:11007778</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus globigii migula 1900]]
[[Category: Bacillus subtilis]]
[[Category: Ha, B H]]
[[Category: Large Structures]]
[[Category: Hong, S K]]
[[Category: Ha BH]]
[[Category: Hwang, K Y]]
[[Category: Hong SK]]
[[Category: Kim, E E]]
[[Category: Hwang KY]]
[[Category: Kim, K H]]
[[Category: Kim EE]]
[[Category: Kim, S J]]
[[Category: Kim K-H]]
[[Category: Enoyl-acp reductase]]
[[Category: Kim SJ]]
[[Category: Fatty acid synthesis]]
[[Category: Nadh binding]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Rossmann-like fold]]

Latest revision as of 16:55, 1 November 2023

Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and INH)

3oig, resolution 1.25Å

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