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==Crystal structure of Marburg virus VP24==
==Crystal structure of Marburg virus VP24==
<StructureSection load='4or8' size='340' side='right' caption='[[4or8]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='4or8' size='340' side='right'caption='[[4or8]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4or8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lake_victoria_marburgvirus_(strain_musoke-80) Lake victoria marburgvirus (strain musoke-80)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OR8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4or8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Marburg_virus_-_Musoke,_Kenya,_1980 Marburg virus - Musoke, Kenya, 1980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OR8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33727 Lake Victoria marburgvirus (strain Musoke-80)])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.654&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4or8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4or8 OCA], [http://pdbe.org/4or8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4or8 RCSB], [http://www.ebi.ac.uk/pdbsum/4or8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4or8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4or8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4or8 OCA], [https://pdbe.org/4or8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4or8 RCSB], [https://www.ebi.ac.uk/pdbsum/4or8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4or8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP24_MABVM VP24_MABVM]] May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.  
[https://www.uniprot.org/uniprot/VP24_MABVM VP24_MABVM] May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting beta-shelf and an alternate conformation of the N-terminal polypeptide.
 
Crystal Structure of Marburg Virus VP24.,Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO J Virol. 2014 May;88(10):5859-63. doi: 10.1128/JVI.03565-13. Epub 2014 Feb 26. PMID:24574400<ref>PMID:24574400</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4or8" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[VP24|VP24]]
*[[VP24|VP24]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Abelson, D]]
[[Category: Large Structures]]
[[Category: Bornholdt, Z]]
[[Category: Marburg virus - Musoke, Kenya, 1980]]
[[Category: Saphire, E O]]
[[Category: Abelson D]]
[[Category: Zhang, A P.P]]
[[Category: Bornholdt Z]]
[[Category: Ebola]]
[[Category: Saphire EO]]
[[Category: Marburg]]
[[Category: Zhang APP]]
[[Category: Protein]]
[[Category: Pyramidal fold]]
[[Category: Viral]]
[[Category: Viral protein]]
[[Category: Virus]]
[[Category: Vp24]]

Latest revision as of 12:41, 1 March 2024

Crystal structure of Marburg virus VP24

4or8, resolution 2.65Å

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