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==Crystal structures of rat VDR-LBD with W282R mutation==
==Crystal structures of rat VDR-LBD with W282R mutation==
<StructureSection load='3vt8' size='340' side='right' caption='[[3vt8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3vt8' size='340' side='right'caption='[[3vt8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VT8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VT8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YI3:(1R,3R,7E,9BETA,17BETA)-9-BUTYL-17-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YI3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zlc|2zlc]], [[3vt3|3vt3]], [[3vt4|3vt4]], [[3vt5|3vt5]], [[3vt6|3vt6]], [[3vt7|3vt7]], [[3vt9|3vt9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YI3:(1R,3R,7E,9BETA,17BETA)-9-BUTYL-17-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YI3</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt8 OCA], [https://pdbe.org/3vt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vt8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt8 OCA], [http://pdbe.org/3vt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vt8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Ikura, T]]
[[Category: Rattus norvegicus]]
[[Category: Ito, N]]
[[Category: Ikura T]]
[[Category: Nakabayashi, M]]
[[Category: Ito N]]
[[Category: Shimizu, M]]
[[Category: Nakabayashi M]]
[[Category: Hormone receptor]]
[[Category: Shimizu M]]
[[Category: Transcription]]
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