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==Crystal structure of porcine pancreatic phospholipase A2 complexed with berberine==
==Crystal structure of porcine pancreatic phospholipase A2 complexed with berberine==
<StructureSection load='4dbk' size='340' side='right' caption='[[4dbk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4dbk' size='340' side='right'caption='[[4dbk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l69 3l69] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tt5 3tt5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DBK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l69 3l69] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tt5 3tt5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p2p|4p2p]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbk OCA], [https://pdbe.org/4dbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbk RCSB], [https://www.ebi.ac.uk/pdbsum/4dbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbk OCA], [http://pdbe.org/4dbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dbk RCSB], [http://www.ebi.ac.uk/pdbsum/4dbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  
[https://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.


==See Also==
==See Also==
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Abhilash, J]]
[[Category: Abhilash J]]
[[Category: Haridas, M]]
[[Category: Haridas M]]
[[Category: Naveen, C D]]
[[Category: Naveen CD]]
[[Category: Prasanth, G K]]
[[Category: Prasanth GK]]
[[Category: Sadasivan, C]]
[[Category: Sadasivan C]]
[[Category: Berberine]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Monomeric protein]]
Retrieved from "https://proteopedia.org/4dbk"