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==Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution==
==Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution==
<StructureSection load='3ld9' size='340' side='right' caption='[[3ld9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3ld9' size='340' side='right'caption='[[3ld9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ld9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ehrcr Ehrcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ld9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ehrlichia_chaffeensis_str._Arkansas Ehrlichia chaffeensis str. Arkansas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LD9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, ECH_0229 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=205920 EHRCR])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ld9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld9 OCA], [https://pdbe.org/3ld9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ld9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ld9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ld9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld9 OCA], [http://pdbe.org/3ld9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ld9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ld9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KTHY_EHRCR KTHY_EHRCR]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).  
[https://www.uniprot.org/uniprot/KTHY_EHRCR KTHY_EHRCR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ld9_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ld9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Thymidylate kinase|Thymidylate kinase]]
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ehrcr]]
[[Category: Ehrlichia chaffeensis str. Arkansas]]
[[Category: DTMP kinase]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Als collaborative crystallography]]
[[Category: Atp-binding]]
[[Category: Ehrlichia chaffeensis]]
[[Category: Emerald biostructure]]
[[Category: Kinase]]
[[Category: Niaid]]
[[Category: Nih]]
[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide-binding]]
[[Category: Sbri]]
[[Category: Ssgcid]]
[[Category: Thymidylate kinase]]
[[Category: Transferase]]
[[Category: Uw]]
Retrieved from "https://proteopedia.org/3ld9"