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==Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant Y317A==
==Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant Y317A==
<StructureSection load='4u8m' size='340' side='right' caption='[[4u8m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4u8m' size='340' side='right'caption='[[4u8m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u8m]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U8M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u8m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U8M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u8i|4u8i]], [[4u8j|4u8j]], [[4u8k|4u8k]], [[4u8l|4u8l]], [[4u8n|4u8n]], [[4u8o|4u8o]], [[4u8p|4u8p]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u8m OCA], [https://pdbe.org/4u8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u8m RCSB], [https://www.ebi.ac.uk/pdbsum/4u8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u8m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u8m OCA], [http://pdbe.org/4u8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u8m RCSB], [http://www.ebi.ac.uk/pdbsum/4u8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u8m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLFA_ASPFM GLFA_ASPFM] UDP-galactopyranose mutase, key flavoenzyme of galactofuranose metabolism that catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to UDP-galactofuranose, the donor used by various galacto-furanosyltransferases (PubMed:16207086, PubMed:18552284, PubMed:22334662, PubMed:23036087, PubMed:25412209, PubMed:26836146). Controls the biosynthesis of galactomannan and galactofuranose containing glycoconjugates (PubMed:18552284). The flavin functions as nucleophile, forming a flavin-sugar adduct that facilitates galactose-ring opening and contraction (PubMed:26836146). The binding of UDP-galactopyranose induces profound conformational changes in the enzyme and two loops on opposite sides of the active site move toward each other by over 10 Angstroms to cover the substrate and create a closed active site (PubMed:22334662).<ref>PMID:16207086</ref> <ref>PMID:18552284</ref> <ref>PMID:22334662</ref> <ref>PMID:23036087</ref> <ref>PMID:25412209</ref> <ref>PMID:26836146</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[UDP-galactopyranose mutase|UDP-galactopyranose mutase]]
*[[UDP-galactopyranose mutase 3D structures|UDP-galactopyranose mutase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: UDP-galactopyranose mutase]]
[[Category: Aspergillus fumigatus]]
[[Category: Chaudhary, R]]
[[Category: Large Structures]]
[[Category: Qureshi, I A]]
[[Category: Chaudhary R]]
[[Category: Tanner, J J]]
[[Category: Qureshi IA]]
[[Category: Flavin adenine dinucleotide binding]]
[[Category: Tanner JJ]]
[[Category: Isomerase]]
[[Category: Mutase]]
[[Category: Nucleotide binding]]
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