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==2.65 Angstrom resolution crystal structure of dTDP-4-dehydrorhamnose reductase (rfbD) from Bacillus anthracis str. Ames in complex with NADP==
==2.65 Angstrom resolution crystal structure of dTDP-4-dehydrorhamnose reductase (rfbD) from Bacillus anthracis str. Ames in complex with NADP==
<StructureSection load='3sc6' size='340' side='right' caption='[[3sc6]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='3sc6' size='340' side='right'caption='[[3sc6]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sc6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SC6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sc6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SC6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS1138, BA_1231, GBAA_1231, rfbD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-dehydrorhamnose_reductase dTDP-4-dehydrorhamnose reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.133 1.1.1.133] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sc6 OCA], [https://pdbe.org/3sc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sc6 RCSB], [https://www.ebi.ac.uk/pdbsum/3sc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sc6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sc6 OCA], [http://pdbe.org/3sc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sc6 RCSB], [http://www.ebi.ac.uk/pdbsum/3sc6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sc6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A6L7H7R4_BACAN A0A6L7H7R4_BACAN] Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.[RuleBase:RU364082]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DTDP-4-dehydrorhamnose reductase]]
[[Category: Bacillus anthracis str. Ames]]
[[Category: Anderson, W F]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Halavaty, A S]]
[[Category: Halavaty AS]]
[[Category: Kuhn, M]]
[[Category: Kuhn M]]
[[Category: Minasov, G]]
[[Category: Minasov G]]
[[Category: Peterson, S]]
[[Category: Peterson S]]
[[Category: Shuvalova, L]]
[[Category: Shuvalova L]]
[[Category: Bacillus anthracis str. ame]]
[[Category: Catalyzes formation of dtdp-4-dehydro-6-deoxy-l-mannose]]
[[Category: Csgid]]
[[Category: Dtdp-4-dehydrorhamnose reductase]]
[[Category: Infectious disease]]
[[Category: Nadph and h+ from dtdp-6-deoxy-l-mannose and nadp+]]
[[Category: Oxidoreductase]]
[[Category: Rfbd]]
[[Category: Rhamnose biosynthetic pathway]]
[[Category: Rossmann fold]]

Latest revision as of 12:53, 14 March 2024

2.65 Angstrom resolution crystal structure of dTDP-4-dehydrorhamnose reductase (rfbD) from Bacillus anthracis str. Ames in complex with NADP

3sc6, resolution 2.65Å

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