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==Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis==
==Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis==
<StructureSection load='3r1f' size='340' side='right' caption='[[3r1f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3r1f' size='340' side='right'caption='[[3r1f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3r1f]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1F FirstGlance]. <br>
<table><tr><td colspan='2'>[[3r1f]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R1F FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">espR, MT3964, Rv3849 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1f OCA], [http://pdbe.org/3r1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3r1f RCSB], [http://www.ebi.ac.uk/pdbsum/3r1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1f OCA], [https://pdbe.org/3r1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r1f RCSB], [https://www.ebi.ac.uk/pdbsum/3r1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU]] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>
[https://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cox, J S]]
[[Category: Large Structures]]
[[Category: Dovey, C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Finer-Moore, J]]
[[Category: Cox JS]]
[[Category: Rosenberg, O S]]
[[Category: Dovey C]]
[[Category: Stroud, R M]]
[[Category: Finer-Moore J]]
[[Category: Helix-turn-helix]]
[[Category: Rosenberg OS]]
[[Category: Helix-turn-helix transcription factor]]
[[Category: Stroud RM]]
[[Category: Transcription]]
[[Category: Transcription factor]]
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