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| ==Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob== | | ==Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob== |
| <StructureSection load='3o8e' size='340' side='right' caption='[[3o8e]], [[Resolution|resolution]] 2.84Å' scene=''> | | <StructureSection load='3o8e' size='340' side='right'caption='[[3o8e]], [[Resolution|resolution]] 2.84Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[3o8e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Human_adenovirus_11 Human adenovirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O8E FirstGlance]. <br> | | <table><tr><td colspan='2'>[[3o8e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_11 Human adenovirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8E FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD46, MCP, MIC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10541 Human adenovirus 11])</td></tr> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8e OCA], [http://pdbe.org/3o8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o8e RCSB], [http://www.ebi.ac.uk/pdbsum/3o8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8e ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8e OCA], [https://pdbe.org/3o8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8e RCSB], [https://www.ebi.ac.uk/pdbsum/3o8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8e ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Disease ==
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| [[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:[http://omim.org/entry/612922 612922]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations.<ref>PMID:14615110</ref> <ref>PMID:14566051</ref> <ref>PMID:16621965</ref> <ref>PMID:16386793</ref> <ref>PMID:20513133</ref>
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| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.<ref>PMID:10843656</ref> <ref>PMID:12540904</ref> | | [https://www.uniprot.org/uniprot/Q772X2_9ADEN Q772X2_9ADEN] |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Human]] | | [[Category: Homo sapiens]] |
| [[Category: Human adenovirus 11]] | | [[Category: Human adenovirus 11]] |
| [[Category: Casasnovas, J M]] | | [[Category: Large Structures]] |
| [[Category: Persson, B D]] | | [[Category: Casasnovas JM]] |
| [[Category: Schmitz, N B]] | | [[Category: Persson BD]] |
| [[Category: Stehle, T]] | | [[Category: Schmitz NB]] |
| [[Category: Adenovirus]] | | [[Category: Stehle T]] |
| [[Category: Cd46]]
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| [[Category: Cell adhesion - immune system complex]]
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| [[Category: Cell adhesion-immune system complex]]
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| [[Category: Cell adhesion-immunity complex]]
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| [[Category: Complement control protein]]
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| [[Category: Fiber knob]]
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| [[Category: Short consensus repeat]]
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| [[Category: Virus-receptor interaction]]
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