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==Structure of plant small GTPase OsRac1 complexed with the non-hydrolyzable GTP analog GMPPNP==
==Structure of plant small GTPase OsRac1 complexed with the non-hydrolyzable GTP analog GMPPNP==
<StructureSection load='4u5x' size='340' side='right' caption='[[4u5x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4u5x' size='340' side='right'caption='[[4u5x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u5x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U5X FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa_Japonica_Group Oryza sativa Japonica Group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5x OCA], [http://pdbe.org/4u5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u5x RCSB], [http://www.ebi.ac.uk/pdbsum/4u5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5x ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5x OCA], [https://pdbe.org/4u5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5x RCSB], [https://www.ebi.ac.uk/pdbsum/4u5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RAC1_ORYSJ RAC1_ORYSJ]] Small GTPase playing a general role in disease resistance signaling pathway. Acts downstream of heterotrimeric G protein alpha subunit. Regulates cell death and reactive oxygen species production, probably through NADPH oxidase. Also involved in sphingolipid elicitor (SE)-dependent defense signaling. Activates phytoalexin production and alters defense-related genes. Down-regulates metallothionein 2b, a reactive oxygen scavenger.<ref>PMID:10485927</ref> <ref>PMID:11149940</ref> <ref>PMID:12237405</ref> <ref>PMID:15220467</ref>
[https://www.uniprot.org/uniprot/RAC1_ORYSJ RAC1_ORYSJ] Small GTPase playing a general role in disease resistance signaling pathway. Acts downstream of heterotrimeric G protein alpha subunit. Regulates cell death and reactive oxygen species production, probably through NADPH oxidase. Also involved in sphingolipid elicitor (SE)-dependent defense signaling. Activates phytoalexin production and alters defense-related genes. Down-regulates metallothionein 2b, a reactive oxygen scavenger.<ref>PMID:10485927</ref> <ref>PMID:11149940</ref> <ref>PMID:12237405</ref> <ref>PMID:15220467</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4u5x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4u5x" style="background-color:#fffaf0;"></div>
==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fujiwara, T]]
[[Category: Large Structures]]
[[Category: Kojima, C]]
[[Category: Oryza sativa Japonica Group]]
[[Category: Kosami, K]]
[[Category: Fujiwara T]]
[[Category: Nakagawa, A]]
[[Category: Kojima C]]
[[Category: Ohki, I]]
[[Category: Kosami K]]
[[Category: Shimamoto, K]]
[[Category: Nakagawa A]]
[[Category: Plant]]
[[Category: Ohki I]]
[[Category: Rac]]
[[Category: Shimamoto K]]
[[Category: Small gtpase]]
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