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==Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)==
==Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)==
<StructureSection load='4jw3' size='340' side='right' caption='[[4jw3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4jw3' size='340' side='right'caption='[[4jw3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jw3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_malayensis"_mcbride_et_al. "streptomyces malayensis" mcbride et al.] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JW3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_malayensis Streptomyces malayensis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JW3 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ltm|3ltm]], [[4jw2|4jw2]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1918 "Streptomyces malayensis" McBride et al.])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jw3 OCA], [https://pdbe.org/4jw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jw3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jw3 OCA], [http://pdbe.org/4jw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4jw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jw3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCZS_STRML NCZS_STRML]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.  
[https://www.uniprot.org/uniprot/NCZS_STRML NCZS_STRML] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces malayensis mcbride et al]]
[[Category: Large Structures]]
[[Category: Synthetic construct sequences]]
[[Category: Streptomyces malayensis]]
[[Category: Chevrel, A]]
[[Category: Synthetic construct]]
[[Category: Desmadril, M]]
[[Category: Chevrel A]]
[[Category: Fourati-Kammoun, Z]]
[[Category: Desmadril M]]
[[Category: Graille, M]]
[[Category: Fourati-Kammoun Z]]
[[Category: Guellouz, A]]
[[Category: Graille M]]
[[Category: Minard, P]]
[[Category: Guellouz A]]
[[Category: Tilbeurgh, H van]]
[[Category: Minard P]]
[[Category: Urvoas, A]]
[[Category: Urvoas A]]
[[Category: Valerio-Lepiniec, M]]
[[Category: Valerio-Lepiniec M]]
[[Category: Alpha-helical protein]]
[[Category: Van Tilbeurgh H]]
[[Category: Dna binding protein-de novo protein complex]]
[[Category: Ncs 3tes24 variant]]
[[Category: Protein engineered to interact with protein of interest]]
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