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==Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4==
==Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4==
<StructureSection load='4r1f' size='340' side='right' caption='[[4r1f]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='4r1f' size='340' side='right'caption='[[4r1f]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r1f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R1F FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R1F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zxn|1zxn]], [[1zxm|1zxm]], [[4prx|4prx]], [[1ei1|1ei1]], [[4pu9|4pu9]], [[4prv|4prv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r1f OCA], [https://pdbe.org/4r1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r1f RCSB], [https://www.ebi.ac.uk/pdbsum/4r1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r1f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r1f OCA], [http://pdbe.org/4r1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r1f RCSB], [http://www.ebi.ac.uk/pdbsum/4r1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r1f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TOP2A_HUMAN TOP2A_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:22323612</ref>
[https://www.uniprot.org/uniprot/TOP2A_HUMAN TOP2A_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:22323612</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4r1f" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4r1f" style="background-color:#fffaf0;"></div>
==See Also==
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Schirmer, T]]
[[Category: Homo sapiens]]
[[Category: Stanger, F V]]
[[Category: Large Structures]]
[[Category: Human topoisomerase iia]]
[[Category: Schirmer T]]
[[Category: Isomerase]]
[[Category: Stanger FV]]
Retrieved from "https://proteopedia.org/4r1f"