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==The Crystal Structure of the Salmonella Type III Secretion System Tip Protein SipD in Complex with Deoxycholate==
==The Crystal Structure of the Salmonella Type III Secretion System Tip Protein SipD in Complex with Deoxycholate==
<StructureSection load='3o01' size='340' side='right' caption='[[3o01]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3o01' size='340' side='right'caption='[[3o01]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O01 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o01]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O01 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nzz|3nzz]], [[3o00|3o00]], [[3o02|3o02]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sipD, sspD, STM2883 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o01 OCA], [https://pdbe.org/3o01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o01 RCSB], [https://www.ebi.ac.uk/pdbsum/3o01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o01 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o01 OCA], [http://pdbe.org/3o01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o01 RCSB], [http://www.ebi.ac.uk/pdbsum/3o01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o01 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIPD_SALTY SIPD_SALTY]] Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.<ref>PMID:8522512</ref> <ref>PMID:9194702</ref>
[https://www.uniprot.org/uniprot/SIPD_SALTY SIPD_SALTY] Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.<ref>PMID:8522512</ref> <ref>PMID:9194702</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus typhimurium loeffler 1892]]
[[Category: Large Structures]]
[[Category: Battaile, K P]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Chatterjee, S]]
[[Category: Battaile KP]]
[[Category: DeGuzman, R N]]
[[Category: Chatterjee S]]
[[Category: Lovell, S]]
[[Category: DeGuzman RN]]
[[Category: Nordhues, B A]]
[[Category: Lovell S]]
[[Category: Zhong, D]]
[[Category: Nordhues BA]]
[[Category: Bacterial needle tip protein]]
[[Category: Zhong D]]
[[Category: Cell invasion]]
[[Category: Coiled-coil]]
[[Category: Prgi]]
[[Category: Sipb]]
[[Category: Sipc]]
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