3nbh: Difference between revisions

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==Crystal structure of human RMI1C-RMI2 complex==
==Crystal structure of human RMI1C-RMI2 complex==
<StructureSection load='3nbh' size='340' side='right' caption='[[3nbh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3nbh' size='340' side='right'caption='[[3nbh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nbh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NBH FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nbh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NBH FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nbi|3nbi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbh OCA], [http://pdbe.org/3nbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nbh RCSB], [http://www.ebi.ac.uk/pdbsum/3nbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbh OCA], [https://pdbe.org/3nbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nbh RCSB], [https://www.ebi.ac.uk/pdbsum/3nbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RMI1_HUMAN RMI1_HUMAN]] Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.<ref>PMID:15775963</ref> <ref>PMID:16595695</ref> <ref>PMID:16537486</ref> [[http://www.uniprot.org/uniprot/RMI2_HUMAN RMI2_HUMAN]] Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.<ref>PMID:18923082</ref> <ref>PMID:18923083</ref> 
[https://www.uniprot.org/uniprot/RMI1_HUMAN RMI1_HUMAN] Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.<ref>PMID:15775963</ref> <ref>PMID:16595695</ref> <ref>PMID:16537486</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbh_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbh_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Busygina, V]]
[[Category: Large Structures]]
[[Category: Guo, R]]
[[Category: Busygina V]]
[[Category: Lei, M]]
[[Category: Guo R]]
[[Category: Meetei, A R]]
[[Category: Lei M]]
[[Category: Singh, T R]]
[[Category: Meetei AR]]
[[Category: Sung, P]]
[[Category: Singh TR]]
[[Category: Wan, K]]
[[Category: Sung P]]
[[Category: Wang, F]]
[[Category: Wan K]]
[[Category: Wang, W]]
[[Category: Wang F]]
[[Category: Yang, Y]]
[[Category: Wang W]]
[[Category: Protein binding]]
[[Category: Yang Y]]
[[Category: Rpa-like complex]]
[[Category: Two ob-folds containing complex]]
Retrieved from "https://proteopedia.org/3nbh"