4awl: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==The NF-Y transcription factor is structurally and functionally a sequence specific histone==
==The NF-Y transcription factor is structurally and functionally a sequence specific histone==
<StructureSection load='4awl' size='340' side='right' caption='[[4awl]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
<StructureSection load='4awl' size='340' side='right'caption='[[4awl]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4awl]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4awl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AWL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n1j|1n1j]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awl OCA], [http://pdbe.org/4awl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4awl RCSB], [http://www.ebi.ac.uk/pdbsum/4awl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4awl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4awl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awl OCA], [https://pdbe.org/4awl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4awl RCSB], [https://www.ebi.ac.uk/pdbsum/4awl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4awl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NFYA_HUMAN NFYA_HUMAN]] Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.<ref>PMID:12741956</ref> [[http://www.uniprot.org/uniprot/NFYC_HUMAN NFYC_HUMAN]] Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. [[http://www.uniprot.org/uniprot/NFYB_HUMAN NFYB_HUMAN]] Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
[https://www.uniprot.org/uniprot/NFYA_HUMAN NFYA_HUMAN] Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.<ref>PMID:12741956</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 20:


==See Also==
==See Also==
*[[NF-Y Transcription Factor|NF-Y Transcription Factor]]
*[[Nuclear transcription factor Y|Nuclear transcription factor Y]]
*[[Nuclear transcription factor Y|Nuclear transcription factor Y]]
== References ==
== References ==
Line 26: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bolognesi, M]]
[[Category: Large Structures]]
[[Category: Donati, G]]
[[Category: Bolognesi M]]
[[Category: Forni, C]]
[[Category: Donati G]]
[[Category: Fossati, A]]
[[Category: Forni C]]
[[Category: Gatta, R]]
[[Category: Fossati A]]
[[Category: Gnesutta, N]]
[[Category: Gatta R]]
[[Category: Mantovani, R]]
[[Category: Gnesutta N]]
[[Category: Moras, D]]
[[Category: Mantovani R]]
[[Category: Nardini, M]]
[[Category: Moras D]]
[[Category: Romier, C]]
[[Category: Nardini M]]
[[Category: Vonrhein, C]]
[[Category: Romier C]]
[[Category: Dna-binding]]
[[Category: Vonrhein C]]
[[Category: Nf-y]]
[[Category: Transcription-dna complex]]
Retrieved from "https://proteopedia.org/4awl"