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==STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B==
==Structure of a functional derivative of Clostridium botulinum neurotoxin type B==
<StructureSection load='2xhl' size='340' side='right' caption='[[2xhl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2xhl' size='340' side='right'caption='[[2xhl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xhl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xhl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s0d|1s0d]], [[1epw|1epw]], [[1g9b|1g9b]], [[1f82|1f82]], [[2etf|2etf]], [[1i1e|1i1e]], [[1s0f|1s0f]], [[1g9a|1g9a]], [[1g9c|1g9c]], [[1s0b|1s0b]], [[1s0g|1s0g]], [[1s0c|1s0c]], [[1g9d|1g9d]], [[1z0h|1z0h]], [[1f31|1f31]], [[1s0e|1s0e]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhl OCA], [https://pdbe.org/2xhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhl RCSB], [https://www.ebi.ac.uk/pdbsum/2xhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhl OCA], [http://pdbe.org/2xhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xhl RCSB], [http://www.ebi.ac.uk/pdbsum/2xhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.  
[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Botulinum neurotoxin|Botulinum neurotoxin]]
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Clostridium botulinum]]
[[Category: Bontoxilysin]]
[[Category: Large Structures]]
[[Category: Acharya, K R]]
[[Category: Acharya KR]]
[[Category: Beard, M]]
[[Category: Beard M]]
[[Category: Cadd, V A]]
[[Category: Cadd VA]]
[[Category: Chaddock, J A]]
[[Category: Chaddock JA]]
[[Category: Masuyer, G]]
[[Category: Masuyer G]]
[[Category: Botulism]]
[[Category: Endopeptidase]]
[[Category: Hydrolase]]
[[Category: Membrane domain]]
[[Category: Metalloprotease]]
[[Category: Toxin]]
[[Category: Zinc protease]]
Retrieved from "https://proteopedia.org/2xhl"