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==A ubiquitin ligase-substrate complex==
==A ubiquitin ligase-substrate complex==
<StructureSection load='4i6j' size='340' side='right' caption='[[4i6j]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4i6j' size='340' side='right'caption='[[4i6j]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4i6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I6J FirstGlance]. <br>
<table><tr><td colspan='2'>[[4i6j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I6J FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i6e|4i6e]], [[4i6g|4i6g]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cry2, Kiaa0658 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), FBXL3, FBL3A, FBXL3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SKP1, EMC19, OCP2, SKP1A, TCEB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i6j OCA], [https://pdbe.org/4i6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i6j RCSB], [https://www.ebi.ac.uk/pdbsum/4i6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i6j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i6j OCA], [http://pdbe.org/4i6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i6j RCSB], [http://www.ebi.ac.uk/pdbsum/4i6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i6j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN]] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> [[http://www.uniprot.org/uniprot/FBXL3_HUMAN FBXL3_HUMAN]] Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2.<ref>PMID:17463251</ref> <ref>PMID:23452855</ref> 
[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4i6j" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4i6j" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Bush, M F]]
[[Category: Mus musculus]]
[[Category: Busino, L]]
[[Category: Bush MF]]
[[Category: Hinds, T R]]
[[Category: Busino L]]
[[Category: Marionni, S T]]
[[Category: Hinds TR]]
[[Category: Pagano, M]]
[[Category: Marionni ST]]
[[Category: Saifee, N H]]
[[Category: Pagano M]]
[[Category: Xing, W]]
[[Category: Saifee NH]]
[[Category: Zheng, N]]
[[Category: Xing W]]
[[Category: Circadian clock]]
[[Category: Zheng N]]
[[Category: F-box]]
[[Category: Lrr]]
[[Category: Nucleus]]
[[Category: Period]]
[[Category: Photolyase fold]]
[[Category: Transcription]]
[[Category: Ubiquitination]]
Retrieved from "https://proteopedia.org/4i6j"