4psi: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==PIH1D1/phospho-Tel2 complex==
==PIH1D1/phospho-Tel2 complex==
<StructureSection load='4psi' size='340' side='right' caption='[[4psi]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='4psi' size='340' side='right'caption='[[4psi]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4psi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PSI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4psi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PSI FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4psf|4psf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIH1D1, NOP17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4psi OCA], [https://pdbe.org/4psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4psi RCSB], [https://www.ebi.ac.uk/pdbsum/4psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4psi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4psi OCA], [http://pdbe.org/4psi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4psi RCSB], [http://www.ebi.ac.uk/pdbsum/4psi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4psi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TELO2_HUMAN TELO2_HUMAN]] Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.<ref>PMID:12670948</ref> <ref>PMID:20810650</ref> 
[https://www.uniprot.org/uniprot/PIHD1_HUMAN PIHD1_HUMAN]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Boulton, S J]]
[[Category: Large Structures]]
[[Category: Flower, T G]]
[[Category: Boulton SJ]]
[[Category: Horejsi, Z]]
[[Category: Flower TG]]
[[Category: Smerdon, S J]]
[[Category: Horejsi Z]]
[[Category: Stach, L]]
[[Category: Smerdon SJ]]
[[Category: Alpha]]
[[Category: Stach L]]
[[Category: Beta]]
[[Category: Phospho-binding]]
[[Category: Phsophorylation]]
[[Category: Protein binding]]
[[Category: Tel2]]
Retrieved from "https://proteopedia.org/4psi"