5jdp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==E73V mutant of the human voltage-dependent anion channel==
==E73V mutant of the human voltage-dependent anion channel==
<StructureSection load='5jdp' size='340' side='right' caption='[[5jdp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5jdp' size='340' side='right'caption='[[5jdp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jdp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JDP FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JDP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdp OCA], [http://pdbe.org/5jdp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jdp RCSB], [http://www.ebi.ac.uk/pdbsum/5jdp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdp ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdp OCA], [https://pdbe.org/5jdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jdp RCSB], [https://www.ebi.ac.uk/pdbsum/5jdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN]] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref>
[https://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 18:
</div>
</div>
<div class="pdbe-citations 5jdp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jdp" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Becker, S]]
[[Category: Homo sapiens]]
[[Category: Giller, K]]
[[Category: Large Structures]]
[[Category: Griesinger, C]]
[[Category: Becker S]]
[[Category: Jaremko, L]]
[[Category: Giller K]]
[[Category: Jaremko, M]]
[[Category: Griesinger C]]
[[Category: Schmidt, C]]
[[Category: Jaremko L]]
[[Category: Villinger, S]]
[[Category: Jaremko M]]
[[Category: Zweckstetter, M]]
[[Category: Schmidt C]]
[[Category: Membrane protein]]
[[Category: Villinger S]]
[[Category: Protein dynamic]]
[[Category: Zweckstetter M]]
[[Category: Relaxation]]
[[Category: Sparse data]]
[[Category: Structure refinement]]
Retrieved from "https://proteopedia.org/5jdp"