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[[Image:1ngt.gif|left|200px]]


{{Structure
==The Role of Minor Groove Functional Groups in DNA Hydration==
|PDB= 1ngt |SIZE=350|CAPTION= <scene name='initialview01'>1ngt</scene>, resolution 2.04&Aring;
<StructureSection load='1ngt' size='340' side='right'caption='[[1ngt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene>
<table><tr><td colspan='2'>[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [https://pdbe.org/1ngt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB], [https://www.ebi.ac.uk/pdbsum/1ngt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngt ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [http://www.ebi.ac.uk/pdbsum/1ngt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''The Role of Minor Groove Functional Groups in DNA Hydration'''
[[Category: Lan T]]
 
[[Category: McLaughlin LW]]
 
[[Category: Williams LD]]
==Overview==
[[Category: Woods KK]]
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.
 
==About this Structure==
1NGT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].
 
==Reference==
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595562 12595562]
[[Category: Protein complex]]
[[Category: Lan, T.]]
[[Category: McLaughlin, L W.]]
[[Category: Williams, L D.]]
[[Category: Woods, K K.]]
[[Category: dna conformation]]
[[Category: modified base]]
[[Category: spine of hydration]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:30:11 2008''

Latest revision as of 07:56, 14 February 2024

The Role of Minor Groove Functional Groups in DNA Hydration

1ngt, resolution 2.04Å

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