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==Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4==
==Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4==
<StructureSection load='4iy0' size='340' side='right' caption='[[4iy0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4iy0' size='340' side='right'caption='[[4iy0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4iy0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IY0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4iy0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IY0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iy2|4iy2]], [[4iy3|4iy3]], [[4iy4|4iy4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNNM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iy0 OCA], [https://pdbe.org/4iy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iy0 RCSB], [https://www.ebi.ac.uk/pdbsum/4iy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iy0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iy0 OCA], [http://pdbe.org/4iy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iy0 RCSB], [http://www.ebi.ac.uk/pdbsum/4iy0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iy0 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).  
[https://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Accardi, A]]
[[Category: Large Structures]]
[[Category: Corral-Rodriguez, M A]]
[[Category: Accardi A]]
[[Category: Diercks, T]]
[[Category: Corral-Rodriguez MA]]
[[Category: Encinar, J A]]
[[Category: Diercks T]]
[[Category: Ereno-Orbea, J]]
[[Category: Encinar JA]]
[[Category: Gomez-Garcia, I]]
[[Category: Ereno-Orbea J]]
[[Category: Martinez-Cruz, L A]]
[[Category: Gomez-Garcia I]]
[[Category: Muller, D]]
[[Category: Martinez-Cruz LA]]
[[Category: Oyenarte, I]]
[[Category: Muller D]]
[[Category: Spiwok, V]]
[[Category: Oyenarte I]]
[[Category: Stuiver, M]]
[[Category: Spiwok V]]
[[Category: Terashima, H]]
[[Category: Stuiver M]]
[[Category: Bateman domain]]
[[Category: Terashima H]]
[[Category: Cb]]
[[Category: Cytosol]]
[[Category: Magnesium sensor]]
[[Category: Magnesium transporter]]
[[Category: Metal transport]]

Latest revision as of 08:53, 20 March 2024

Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4

4iy0, resolution 1.90Å

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